• br Conclusion br Competing interests

  2023-10-01

  

  Conclusion Competing interests Funding The Bolger Prostate Cancer Research Fund (no grant number), the National Institute of General Medical Sciences of the National Institutes of Health (1-R01-GM58553, G. B. Bolger, principal investigator), and the National Cancer Institute of the NIH to t

• br The lipoxygenase pathway and microvascular complications

  2023-10-01

  

  The 12/15-lipoxygenase pathway and microvascular complications of diabetes The 12/15-lipoxygenase pathway in adipose tissue Only recently has adipose tissue been recognized as a highly metabolically active endocrine organ imparting profound local and systemic inflammatory effects. Adipose tiss

• Fig A shows a schematic representation of

  2023-10-01

  

  Fig. 2A shows a schematic representation of histological results according to the Franklin and Paxinos Mouse Brain Atlas (2001). The black circles represent the sites of drug infusion that were on-target within the amygdala. Gray circles represent the animals that had infusion locations outside the

• Screening a selection of analogues from this library

  2023-09-28

  

  Screening a selection of analogues from this library against the panel of 26 kinases (16, 22, and 24 were screened at 30 μM due to poor solubility; 17 tested at 100 μM) generally demonstrated an increase in activity compared to Pseudo-UTP 3 (Fig. 3, Fig. 6). The benzamide analogue 16 demonstrated >

• br Conflict of interest statement br Acknowledgments br

  2023-09-28

  

  Conflict of interest statement Acknowledgments Introduction Cellular responses to genotoxic stress in eukaryotic cells are coordinated by members of the phosphoinositide kinase related protein kinase (PIKK) family. Two members of this family, Ataxia–Telangiectasia mutated (ATM) and ATM and

• Nicotine sale Estrogen exerts its genomic action via estroge

  2023-09-28

  

  Estrogen exerts its genomic action via Nicotine sale nuclear receptor: ERα and ERβ. The distribution of ERα and/or ERβ positive neurons in CNS of different species has been mapped extensively by various methods [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], although there are some diff

• Rottlerin br Conclusions br Declarations br

  2023-09-28

  

  Conclusions Declarations Introduction The classical term of endocrine disruption includes any agent that interferes with the action of hormones within the human body; these agents are therefore named endocrine disruptors. Among these agents, that are mainly environmental chemicals (pollutan

• Based on the general structure function principle in

  2023-09-28

  

  Based on the general structure-function principle in biology [[19], [20], [21]], toxic oligomers are expected to have well-defined three-dimensional structures to carry out their pathological functions. A common amyloid toxicity mechanism also suggests that toxic oligomers of different amyloid prote

• br Experimental procedures br Results br

  2023-09-28

  

  Experimental procedures Results Discussion Acknowledgments Introduction β-Adrenergic receptors (β-ARs) belong to the superfamily of membrane proteins termed G protein-coupled receptors. β-ARs are distributed in the effector wst-1 of most of the sympathetic nerve fibers, and the recept

• Our studies suggest that AdipoR and AdipoR genes are express

  2023-09-28

  

  Our studies suggest that AdipoR1 and AdipoR2 genes are expressed in multiple tissues in the chicken wherein both receptors are likely to mediate the physiological effects of adiponectin. We determined the relative expression of AdipoR1 and AdipoR2 mRNA in various tissues and found that skeletal musc

• br Materials and Methods br

  2023-09-28

  

  Materials and Methods Results Discussion Voluminous literature is available describing the regulation of Cy7 maleimide (non-sulfonated) homeostasis by central and peripheral mechanisms in poultry [35,36]. However, the neuroendocrine mechanism(s) of photoperiod induced hypothalamic regulati

• br Conclusions Several lines of evidence have been establish

  2023-09-28

  

  Conclusions Several lines of evidence have been established, which support the adenosine kinase hypothesis of epileptogenesis, which is based on a sequence of events leading from acute MnTBAP Chloride injury to initial downregulation of ADK, rise in extracellular adenosine, changes in astrocytic

• Since pyrrolopyrimidine dithiolanes and both displayed parti

  2023-09-28

  

  Since pyrrolopyrimidine dithiolanes and both displayed particularly excellent levels of ACK1 inhibition, these analogs were viewed as potential candidates for further investigation in tumor xenograft experiments. While in vitro metabolic studies indicated that pyrrolidine was predicted to be sign

• Qualitative inspection of the single

  2023-09-28

  

  Qualitative inspection of the single-channel traces presented in both Figures 3 and 4 shows that within bursts of activity, βAnc-containing AChRs display a marked reduction in open probability. To quantify these differences in single-channel behavior, we performed dwell-time analysis under high-reso

• The synthesis and secretion of adrenal

  2023-09-27

  

  The synthesis and secretion of adrenal androgens is apparently unique to humans and nonhuman primates, and requires the expression of key mediators such as CYP17 [26]. Endocrine control of CYP17 expression in rhesus monkeys is comparable to that in humans [27]. An analysis of baboon cDNA for CYP17 s

14639 records 273/976 page Previous Next First page 上5页 271272273274275 下5页 Last page