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This study evaluated the anti tumor
2024-10-29
This study evaluated the anti-tumor influences of LA against HepG2 LY2784544 in vivro, and investigated the molecular mechanisms of inducing apoptosis. Overall, our studies suggested that LA is a promising anti-cancer drug and a possible novel therapeutic agent directed toward the mitochondrial-med
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br Introduction The apelin receptor angiotensin receptor
2024-10-29
Introduction The apelin receptor (angiotensin receptor-like 1, APJ) is a seven transmembrane receptor (7TMR) that belongs to the class A peptidergic G protein-coupled receptors (GPCR) superfamily [1]. The endogenous ligands of APJ are the different isoforms of apelin (namely apelin-13, −17, and −
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br Results and discussion The
2024-10-29
Results and discussion The soil fungus PSU-RSPG37 (BCC56870) was isolated from soil samples collected from Rajjaprabha Dam, Suratthani Province, Thailand. The fungus was deposited at BIOTEC Culture Collection, National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Pa
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br Method of literature search br Disclosures br Acknowledgm
2024-10-29
Method of literature search Disclosures Acknowledgment The authors thank and acknowledge Mrs. Jaini Parekh, BFA, for illustrating the diagram in Figure 1. An overview of angiogenesis Angiogenesis is a biological process through which there is the formation of new blood vessels from pre-
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The only psychostimulant treatment option
2024-10-28
The only psychostimulant treatment option in Turkey is methylphenidate (Çetin et al., 2015). It is broken down by carboxylase enzyme (CES1) (Sun et al., 2004). From the point of pharmacokinetics, it may be suggested that CES1 gene polymorphisms may be the key responsible factors in patients resistan
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br Adiponectin receptors in colorectal cancer development
2024-10-28
Adiponectin receptors in colorectal cancer development APN receptors expressed in CRC tissue may mediate its effects on cell expansion and cell death (Byeon et al., 2010). It was observed that the expression of AdipoR1 and 2 is higher in CRC tissue than in counterpart healthy tissues (Williams e
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MLN9708 br Material and methods br Results br Discussion To
2024-10-28
Material and methods Results Discussion To develop a novel regenerative and/or neuroprotective therapy for optic neuropathy, including glaucoma, numerous studies have tested new candidates favorable to RGC survival and axon regeneration. Among the many candidate drugs, AdoR modulators are o
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In pioneering work from Ikeda and colleagues showed that GMF
2024-10-28
In 2006, pioneering work from Ikeda and colleagues showed that GMF localizes to and regulates the Pyrrolidinedithiocarbamate ammonium cytoskeleton (see Glossary), and noted its sequence similarity to ADF/cofilin[11]. In 2009, the structure of GMF [6] was solved, revealing it to be a bona fide membe
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Thus one possible target for CRPC treatment is the
2024-10-28
Thus one possible target for CRPC treatment is the enzyme 17,20-lyase, which plays a crucial role in androgen biosynthesis. This is because inhibition of 17,20-lyase would be expected to decrease serum androgen levels secreted not only by the testes but also by the adrenal glands.7, 8, 9 In recent
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Furthermore we also found that the basic
2024-10-28
Furthermore, we also found that the basic level of ROS was markedly lower in mtDNA-reduced SW480 Streptozocin than that in the parent cells. Endogenous ROS is most notably produced at the sites of complex I and complex III [5], it might be plausible that the decreased quantity of ROS observed in mt
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br Conflicts of interest br Introduction
2024-10-28
Conflicts of interest Introduction Photodynamic Therapy (PDT) is a technique used for the treatment of several malignant and non malignant diseases (Akimoto, 2016, Keyal, Bhatta, Wang, 2016, Morton, Szeimies, Sidoroff, Wennberg, Basset-Seguin, Calzavara-Pinton, Gilaberte, Hofbauer, Hunger, Kar
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Protein arrays provide a new
2024-10-26
Protein arrays provide a new approach for the identification of substrates for several protein-modifying enzymes. For example, protein kinase substrate identification, which constitutes an important aspect of pathway mapping because of the prevalence of these substrates in biological pathways. MacBe
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Since ARBs strongly reduce inflammation it was hypothesized
2024-10-26
Since ARBs strongly reduce inflammation, it was hypothesized that the protective effects on cognition were the result of reduction of inflammation and amelioration of neurogenic decrease. However, ARB treatment did not normalize increased inflammation and neurogenic loss. For this reason, the protec
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br Materials and methods br
2024-10-26
Materials and methods Results Discussion Our results revealed that LPS injection in rats impaired fear memory in the PA task. This results are in agreement with the most of previous studies reported that following acute [23,24,39,[45], [46], [47]] or chronic systemic doripenem [30] fear le
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Liao and van Linden et al divided the gap
2024-10-26
Liao [47] and van Linden et al. [48] divided the gap between the N-terminal and C-terminal lobes into a front cleft or pocket, a gate area, and a back cleft. The back pocket corresponds to the gate area and the back cleft. The front cleft includes the Gly-rich loop, the hinge, the linker connecting
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