• A number of models have been proposed in order to

  2022-01-18

  

  A number of models have been proposed in order to explain the mechanisms of protein transport through nuclear pore complexes. One theory is that the transport is mediated by specific peptide signals known as NLSs. The classical NLSs are short sequences containing a high proportion of the positively

• br STAR Methods br Acknowledgments

  2022-01-18

  

  STAR★Methods Acknowledgments We would like to thank Dr. Xiping Cheng for help with the immunohistochemistry staining, Qi Su for help with gene expression analysis, and Dr. Chaoying Liang at the UTSW Genomics Microarray Core facility for assistance on RNA-seq. W.-H.L. was supported by grant awa

• Whereas accurate measurement of glucagon in humans has been

  2022-01-18

  

  Whereas accurate measurement of glucagon in humans has been possible since the early 1950s proper measurements in rodents, have not. That said, plasma concentrations of glucagon have been reported in rodent studies [21] using C-terminal specific methods but what has been lacking is the secretory dyn

• Amongst oxidants that we have studied PMS is unique in

  2022-01-18

  

  Amongst oxidants that we have studied, PMS is unique in having a greater effect in deoxygenated cells. The resulting phenotype shows some similarities with the increased cation permeability shown by deoxygenated sickle fluorescent probes [27]. It is interesting to consider why PMS has this effect.

• PF-670462 br Conclusions There are a number of

  2022-01-18

  

  Conclusions There are a number of factors that affect the transit of solutes through gap junction channels. Fig. 4 provides a simplified illustration of those factors. First is the cytoplasmic vestibule through which all permeable solutes must pass to gain access to the pore. In an equivalent cir

• SCPNs and CPNs exhibit similar strength of electrical coupli

  2022-01-18

  

  SCPNs and CPNs exhibit similar strength of electrical coupling (Maruoka et al., 2017) and had similar membrane properties (Experimental Procedures), and showed no significant difference in amplification and synchronization (Figs. 2E and 3C). However, a subset of CPNs exhibit very strong electrical c

• Riociguat br Concluding remarks br Introduction The hair

  2022-01-18

  

  Concluding remarks Introduction The hair Riociguat of vestibular organs detect linear and rotational head movements, providing sensory information that is essential for normal postural and visual reflexes. Most vestibular hair cells are produced during embryonic development, but they can be lo

• br Materials and methods br Results and

  2022-01-18

  

  Materials and methods Results and discussion Conclusions Notes Declaration of interest statement Acknowledgment This work was supported by the National Natural Science Foundation of China (No. 21775132, 21505112), Scientific Research Foundation of Hunan Provincial Education Departm

• To improve the performance of the

  2022-01-18

  

  To improve the performance of the immunoassay, various nanomaterials including carbon nanospheres [9], gold nanoparticles [10] and transition metal compounds [11] were used to immobilize natural enzymes as the label. Natural enzymes, such as horseradish peroxidase (HRP) [12] and glucose oxidase (GOD

• Compounds were tested for GPR

  2022-01-18

  

  Compounds , were tested for GPR40 activity in a functional assay monitoring calcium flux in CHO GSK2126458 transiently transfected with human GPR40 gene. As shown in , compound was found to be a nanomolar GPR40 agonist, while compound was much less potent than . To explore the structure activity rel

• While earlier reports on ferroptosis did not clarify

  2022-01-18

  

  While earlier reports on ferroptosis did not clarify mitochondrial damage and consequent death signaling in this paradigm of oxidative death, evidence from recent studies in neuronal systems strongly suggested a mechanistic link between enhanced lipid peroxide formation and loss of mitochondrial int

• Mitochondrial is the main source for

  2022-01-18

  

  Mitochondrial is the main source for ROS and ATP generation, and the loss of mitochondrial membrane potential is involved in the alteration of mitochondrial metabolism and mitochondrial failure-induced cell death [33,34]. In this study, we showed that upregulated ZNF32 sustained mitochondrial membra

• Management of HIV treatment with HIV PIs

  2022-01-17

  

  Management of HIV-1 treatment with HIV PIs can be complicated due to wide inter-patient variability in Bupivacaine HCl levels. In certain scenarios, therapeutic drug monitoring (TDM) has been recommended as a useful approach to individualize therapy for HIV-infected patients [[9], [10], [11], [12]]

• Histamine which was used as the

  2022-01-17

  

  Histamine, which was used as the agonist, had low potencies in our functional experiments when compared to its affinity from binding studies (e.g. Lim et al., 2005). This phenomenon is related to the fact that the coupling of the presynaptic receptor to the transduction machinery and the final funct

• The more important effect of pitolisant is related to

  2022-01-17

  

  The more important effect of pitolisant is related to its wake-promoting and arousal activities as a result of enhanced EPZ004777 sale release in animal models (Ligneau, Perrin, et al., 2007). Moreover, its potential in the treatment of severe excessive daytime sleepiness (EDS) in narcoleptic teenag

14639 records 504/976 page Previous Next First page 上5页 501502503504505 下5页 Last page