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br Some general considerations on anterior pituitary
2021-11-08

Some general considerations on anterior pituitary cell type, models, sex and drugs Historically, real-time analysis of native endocrine anterior pituitary cell excitability has been somewhat limited and thus much of the pioneering work on anterior pituitary cell excitability and stimulus-secretio
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Interestingly GAL has also been shown
2021-11-08

Interestingly, GAL has also been shown to be co-expressed and/or secreted in luteinizing hormone releasing hormone (LHRH) (Merchenthaler et al., 1991, Marks et al., 1994) and kisspeptin (KISS) neurons (Porteous et al., 2011). Furthermore, GAL was shown to stimulate luteinizing hormone (LH) secretion
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Indeed another recent study found that the HR
2021-11-08

Indeed, another recent study found that the HR-like cell death triggered in rice epidermal cells by an avirulent or incompatible isolate of the fungal pathogen , which causes blast disease, is a ferroptotic cell death phenomenon (). Similar to the heat shock example given above, elevated levels of
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Finally the optimized leads and were tested
2021-11-08

Finally, the optimized leads (−)- and (−)- were tested in rat model of CIPN (3 and 30 mg/kg, po, qd, administered for 7 days) and the results have been shown in . Under acute set up, after single oral administration at 30 mg/kg, both the compounds exerted significant improvement of the NP condition
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Previous evidence suggests that PRC is an
2021-11-08

Previous evidence suggests that PRC2 is an important regulator of chromatin looping interactions in embryonic stem DCPIB synthesis . The new study by Donaldson-Collier and colleagues provides the first evidence that similar processes may be at play in lymphoma. It is still largely unclear, however,
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AS 101 br Transparency declaration br Acknowledgements br
2021-11-08

Transparency declaration Acknowledgements Hepatitis C Virus (HCV) infection represents a disease of significant global impact that afflicts around 170 million people worldwide., A small proportion of infected people clear the virus naturally, whilst the majority develop chronic hepatitis C
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br Conclusions br Competing interests br Introduction Ethano
2021-11-06

Conclusions Competing interests Introduction Ethanol exposure has been linked to changes in the pattern of histone acetylation and deacetylation through histone acetyltransferases (HATs) and histone deacetylases (HDACs) in the jzl and in peripheral tissues, leading to ethanol dependence-re
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Excessive extracellular glutamate can be removed from brain
2021-11-06

Excessive extracellular glutamate can be removed from 4E1RCat receptor interstitial fluids to the blood plasma for the maintenance of proper extracellular glutamate homeostasis in the mammalian central nervous system [[5], [6], [7]]. The glutamate concentration in the blood plasma increases in case
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Tanshinone IIA---sulfonic sodium Genomic studies have afford
2021-11-06

Genomic studies have afforded new insight into the influence of Tanshinone IIA---sulfonic sodium structure on GR binding. An important clue came from genome-wide mapping of chromatin structure using DNase I hypersensitive site sequencing (DNase-seq), and comparing the locations of open chromatin to
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The usefulness of GIP R antagonism for the treatment
2021-11-06

The usefulness of GIP-R antagonism for the treatment of obesity-diabetes has been revealed in numerous studies employing knockout or chemical blockade of GIP-R signalling.*88, 89, *90, 91, 92, 93, 94, 95, 96, *97 For example, sub-chronic daily administration of (Pro3)GIP to ob/ob mice results in sig
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The receptor binding assay used in our previous
2021-11-06

The receptor binding assay used in our previous study demonstrated that propofol competitively binds to FPR1, thus blocking the downstream signal transduction of FPR1 and inhibiting neutrophil immune activities [8]. In this study, we assessed the pharmacological action of fMMYALF in the presence of
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On correlating acute rejection to different
2021-11-06

On correlating acute rejection to different risk markers by multiple linear regression analysis, we found that serum FasL and serum creatinine were variables that were independently associated with AR. Carstens et al., reported that significant differences were present between acute rejection and ze
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It is not established if ONOO also induces tyrosine nitratio
2021-11-06

It is not established if ONOO− also induces tyrosine nitration of ANT and affects VDAC1 and ANT interaction, as well as the interaction of VDAC1 with HK II, all of which are events that may lead to altered mitochondrial and cellular function. Thus, in this study we examined tyrosine nitration of bot
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It would also be interesting to understand the potential
2021-11-05

It would also be interesting to understand the potential connection between asymmetric histone inheritance and another phenomenon reported by several investigators: selective DNA strand segregation (reviewed by Evano and Tajbakhsh, 2013, Rando, 2007, Tajbakhsh and Gonzalez, 2009). Recent development
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br Materials and methods br Results br Discussions The treat
2021-11-05

Materials and methods Results Discussions The treated tannery effluent (both MF and MF+RO treated) was free from most of the organic and inorganic loadings as reflected from the values of COD, BOD, total kjeldahl nitrogen (TKN) and sulfides etc. Toxicity study of the effluent (both treated
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