• br Conflict of interest br

  2024-09-09

  

  Conflict of interest Acknowledgements Introduction The mitogen-activated protein kinase (MAPK) pathway is an important intracellular signaling system that regulates diverse cellular functions, such as proliferation, differentiation, and apoptosis [1]. Apoptosis signal-regulating kinase 1 (

• br Experimental Section br Results and Discussion br

  2024-09-09

  

  Experimental Section Results and Discussion Conclusions The advantages of the novel enzymo-chemical method for Mn and Co assay are simplicity of analytical procedure and economic effect due to the usage of only one enzyme in the form of apo-enzyme. An effectiveness of the apo-arginase-based

• Although the earlier studies focused on the

  2024-09-09

  

  Although the earlier studies focused on the antioxidant capacity of tocopherols, ascorbic Malonic acid synthesis and carotenoids, then it was noticed that phenolic compounds were more powerful than others (Rice-Evans, Miller, & Paganga, 1996). Phenolic compounds, the most numerous and ubiquitous gr

• In this study we have generated new FRET reporters

  2024-09-09

  

  In this study, we have generated new FRET reporters to screen all submembrane domains of AT1R for interactions with CaM. We identified a new CaM-binding domain on the receptor’s SMD2 (a.a. 125 – 141), confirmed interactions at SMD4JM (a.a. 309 – 327) and characterized the full interacting domain in

• br Discussion Elevated blood BCAA levels are a common featur

  2024-09-06

  

  Discussion Elevated blood BCAA levels are a common feature of a developed pathophysiological state characterized by obesity and IR [4]. It has been suggested that this profile is part of a panel of biomarkers able to predict the onset of more severe complications like diabetes in humans [14]. In

• AR is an enzyme involved in

  2024-09-06

  

  AR is an enzyme involved in conversion of glucose into sorbitol using NADPH as a cofactor [46]. This AR polyol pathway generates sorbitol accumulation and NADPH depletion. NADPH participates in detoxification via glutathione (GSH) reductase pathway [47]. Therefore, reduction of NADPH attenuates remo

• Nrf br AhR br Nrf

  2024-09-06

  

  Nrf2 AhR Nrf2 and AhR: friends or foes for energetic metabolism? Perspectives in carcinogenesis upon xenobiotic exposure Acknowledgements Introduction Integration of endogenous and exogenous signals via appropriate receptors is at the core of biological differentiation and adaptive r

• In conclusion we have shown that mGlu receptors

  2024-09-06

  

  In conclusion, we have shown that mGlu7 receptors negatively regulate α1-adrenergic receptor signalling in heterologous expression systems, clemastine synthesis tissue and living animals. This interaction might represent a protective mechanism aimed at restraining an excessive activation of noradre

• In the current study adiponectin

  2024-09-06

  

  In the current study, adiponectin receptors expressions were detected in both cell lines. AdipoR2 showed equal expression levels, whereas AdipoR1 possessed different expression levels in both cell lines. There was a significant increase in the AdipoR1 mRNA levels in cell lines according to AdipoR2 m

• The enzyme plays an important role

  2024-09-06

  

  The enzyme plays an important role in the purine metabolism of this parasite. Like other parasitic protozoa, T. gondii is incapable of de novo purine biosynthesis and depends totally on preformed purines salvaged from the host (+)-Apogossypol for its purine requirements and survival (Perrotto et al

• Deferiprone br Roles for GMF in

  2024-09-06

  

  Roles for GMF in Endocytic Traffic In addition to its roles in cell migration, GMF regulates actin-dependent endocytosis in yeast and mammals 13, 14, 50, and promotes the turnover of focal adhesions in immune Deferiprone 42, 51. Vinculin, a central component of focal adhesions that anchors cells

• Our studies also reveal the normal

  2024-09-06

  

  Our studies also reveal the normal functional roles of the MIR. Interaction between the MIR loop and the N-terminal α helix nucleates conformational maturation of AChR subunits, thereby promoting assembly of mature AChRs [52], [55]. This interaction in homologous parts of all AChR subunits appears t

• br Experimental section br Results and discussion br Conclus

  2024-09-06

  

  Experimental section Results and discussion Conclusion Acknowledgements This work was financially supported by Recruitment Program of Global Experts, and the Director Foundation of XTIPC, CAS, Grant No. 2015RC011. This work was also financially supported by Natural Science Foundation of

• br Colabeling evidence for ACh and

  2024-09-06

  

  Colabeling evidence for ACh and GABA cotransmission Though functional demonstrations of ACh/GABA cotransmission remain largely limited to the retina and our recent analyses of cortex (Lee et al., 2010, Saunders et al., 2015a, Saunders et al., 2015b), evidence suggestive of ACh/GABA cotransmission

• It is important to note that

  2024-09-06

  

  It is important to note that stable amnesia is, apparently, a general biological phenomenon and can be found in different animal species. In studies on rats, it was found that if reconsolidation of conditioned olfactory aversion memory was impaired by the antagonist of NMDA glutamate receptors, amne

14154 records 61/944 page Previous Next First page 上5页 6162636465 下5页 Last page