• Introduction Enzymes have higher

  2019-09-03

  Introduction Enzymes have higher selectivity, specificity and efficiency than chemical catalysts. Due to their properties and their green chemistry, biocatalysts are widely used in food, textile and pharmaceutical industry [1], [2].

• Our results also showed that the highest

  2019-09-02

  Our results also showed that the highest dose of Astressin2-B increased the rewarding effects of cocaine, since non-defeated animals treated with this dose developed CPP with a sub-threshold dose.

• Introduction Double strand break (DSB) is the

  2019-08-29

  Introduction Double strand break (DSB) is the most deleterious damage that threats DNA integrity. This frequent damage arises from environmental stress like UV, chemical agents or ionizing radiations (IRs).

• Herein we explored by docking studies the

  2019-08-28

  Herein, we explored by docking studies the effectiveness of replacing the dimethyl substitution at C (6) of dihydrotriazine with a folded azaspiro-containing substituent, along with the introduction of differently substituted phenyl- and benzyl-rings or alkyl chains, linked at the position 1 of the main core of the derivatives (see Fig. 1, Fig. 2, Fig. 3).

• Discussion For several decades

  2019-08-27

  Discussion For several decades, the diagnosis of translocation-associated childhood sarcomas with overlapping morphological characteristics has been facilitated by pathognomonic gene fusion detection through RT-PCR or FISH.

• CK1 enzymes belong to a conserved family of

  2019-08-26

  CK1 enzymes belong to a conserved family of serine/threonine protein kinases that plays an important and diverse role in vesicular trafficking, DNA repair, DSLET progression and cytokinesis in organisms from yeast to humans [15].

• Previous in vitro studies have demonstrated

  2019-08-24

  Previous in vitro studies have demonstrated that DNA-PK-deficient cell line (MO59J) is approximately 30-fold more sensitive to radiation than DNA-PK-proficient cell line (MO59K) [31].

• In PSB 36 to drospirenone dydrogestrone

  2019-08-23

  In PSB 36 to drospirenone dydrogestrone acts rather neutral at the aldosterone-, glucocorticoid- and androgen-receptor [12].

• Which other approaches can complement

  2019-08-22

  Which other approaches can complement signaling optogenetics to paint a more complete picture of developmental Erk signaling? For now, the authors have dynamically manipulated Erk signaling but measured the Erk output at steady-state using classic immunofluorescence techniques (Johnson and Toettcher, 2019).

• Structure similarity searches were conducted using the

  2019-08-21

  Structure similarity searches were conducted using the standalone version of the DALI program with the query structures scanned against a local current version of the PDB that has all chains as separate entries (Holm and Sander, 1995).

• One specific PPACKII region that may be

  2019-08-20

  One specific PPACKII region that may be involved in the reduction of anxiety after anti-SVG-30 treatment is the lateral septum which contains a high density of CRF2 receptors [5], [44].

• Besides the enhanced expression of costimulatory

  2019-08-19

  Besides the enhanced expression of costimulatory and adhesion proteins, also the expression of the CD83 surface molecule is strongly enhanced during DC maturation (Banchereau and Steinman 1998; Banchereau et al. 2000).

• Cdc42 which is involved in filopodium

  2019-08-17

  Cdc42, which is involved in filopodium formation, and Rac1, which is involved in lamellipodium formation, engage in cross-talk with one another [25,26,30,31].

• Several reports have exploited the application

  2019-08-16

  Several reports have exploited the application of HRM for detecting differentially methylated DNA. Even though DNA methylation analysis by HRM cannot determine the methylation status of individual CpGs, it does provide a robust and inexpensive method to differentiate DNA based on the overall methylation of a specific amplicon.

• Despite the weak and transient nature

  2019-08-15

  Despite the weak and transient nature of E2–E3 interactions, this binding is required for the transfer of ubiquitin to the substrate.

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