• br Introduction Lung cancer is the leading cause

  2019-10-08

  

  Introduction Lung cancer is the leading cause of cancer-related death worldwide, accounting for more than 1.5 million deaths in 2012. Non–small-cell lung cancers represent approximately 85% of lung neoplasms; among these, squamous cell carcinomas (SCC) account for approximately 30% of cases. The

• In summary our findings show that LPS can activate

  2019-10-08

  

  In summary, our findings show that LPS can activate CysLT2R on microglial Olcegepant pathway to induce microglial inflammation and microglia-dependent neuronal death. Furthermore, pharmacological inhibition or knocking down of CysLT2R expression protects neurons against neurotoxicity via suppressio

• Agglutinin like sequence ALS gene is well characterized

  2019-10-08

  

  Agglutinin-like sequence (ALS) gene is well-characterized gene family in candidiasis due to its importance in pathogenicity of C albicans. Previously, C. albicans ALS1 gene product was reported as cell surface protein that mediates adherence to endothelial and epithelial PSI-7977 clinical in vitro

• Our present data show that

  2019-10-08

  

  Our present data show that neuroleptics can affect CYP3A via a direct interaction with the enzyme and a significant indirect mechanism (enzyme regulation) produced in vivo. The obtained results revealed interactions of the neuroleptics (added in vitro to control liver microsomes, Model I) with rat C

• Conclusions br Acknowledgements The study was supported

  2019-10-08

  

  Conclusions Acknowledgements The study was supported by a grant from the Argentine National Agency for the Promotion of Science and Technology (ANPCyT) (PICT 2012-2649). N.R.S., H.H.O., G.J.H. and F.R. are research career members and N.C.G., E.A., E. H., F.M.R., are fellows of the National Scien

• Sterol regulatory element binding proteins SREBPs regulate

  2019-10-08

  

  Sterol regulatory element binding proteins (SREBPs) regulate transcription of genes involved in fatty Gadodiamide synthesis [38] (fatty acid synthase, and acetyl-CoA carboxylase) as well as triglyceride synthesis [39]. SREBP-1 protein levels are reduced in 3T3-F442A adipocytes [40] and increased in

• In this study new and more extended tables

  2019-10-08

  

  In this study, new and more extended tables of parameters were estimated for pure fluids and binary mixtures that are relevant to biodiesel systems. Also, calculations for glyceride systems will be shown, which is a topic not investigated before with the CPA model. As before [21], [22], [23], [24],

• In previous works Wang et al the PR

  2019-10-08

  

  In previous works (Wang et al. [4,5]), the PR-CPA EoS has been applied to describe the solubilities of hydrocarbons (including methane, ethane, propane, n-butane, n-pentane, n-hexane, benzene, toluene, and ethyl-benzene) and mercaptans (including methyl mercaptan and ethyl mercaptan) in aqueous MDEA

• It was reported that IVM modulates various

  2019-10-08

  

  It was reported that IVM modulates various ion channels, such as type-A GABACls, α7 acetylcholine-gated cation channels, P2X4 ATP-gated cation channels, and glycine-gated chloride Abiraterone in vertebrates (Adelsberger et al., 2000, Khakh et al., 1999, Krause et al., 1998, Krůšek and Zemková, 1994

• SCH-900776 br Materials and methods br Results br Discussion

  2019-10-07

  

  Materials and methods Results Discussion In particular, we showed that pancreatic neuroendocrine tumor SCH-900776 recognize cAMP as a stimulatory signal for cell proliferation. Conversely, cAMP was found to have an inhibitory effect on cell proliferation in bronchial carcinoids cells. The

• The DNA damage response DDR is

  2019-10-07

  

  The DNA damage response (DDR) is a cellular mechanism that protects against DNA damage induced by endogenous and exogenous factors, it includes changes in cellular processes such as VRT752271 kinase regulation, DNA damage repair, apoptosis and chromatin remodeling. In recent years, the DDR has been

• DGK is not the only DGK isoform that has been

  2019-10-07

  

  DGKε is not the only DGK isoform that has been associated with p53. It has been shown that DGKζ binds to p53 and modulates its activity in both the cytoplasm and the nucleus [39]. In the cytosol DGKζ promotes the degradation of p53 through the ubiquitin-proteosome system [39], also a likely mechanis

• br Development of a liquid chromatography mass spectrometry

  2019-10-07

  

  Development of a liquid chromatography-mass spectrometry method to improve detection of PA species detection Liquid chromatography-mass spectrometry (LC-MS) is a powerful tool to detect different molecular species of phospholipids in ampk inhibitor (Houjou et al., 2005, Pulfer and Murphy, 2003).

• Mechanistically GW treatment modulated cytokine

  2019-10-07

  

  Mechanistically, GW2580 treatment modulated cytokine expression within the kidney. We noted a decrease in the levels of TNF, MCP-1, IL-1β, IL-27, and GM-CSF in GW2580 treated mice. Decreased levels of these proinflammatory cytokines likely contributed to the attenuated proteinuria and improved renal

• Stable isotope studies applied to skeletal remains of

  2019-10-07

  

  Stable isotope studies, applied to skeletal remains of early Pacific populations, have shown a trend toward a horticultural diet with temporal variation in response to local environmental conditions (Field et al., 2009; Kinaston and Buckley, 2013; Valentin et al., 2010, Valentin et al., 2014; Kinast

14639 records 962/976 page Previous Next First page 上5页 961962963964965 下5页 Last page