• Normally the activity of the

  2024-12-21

  

  Normally, the activity of the 17,20-lyase increases with the onset of adrenarche [7], [8], [15]. Adrenarche has previously been perceived as a relatively sudden event, occurring physiologically between 6 and 8years of age. However, results from our laboratory clearly indicated that adrenarche is a c

• Dig-11-utp Renal Cell Carcinoma RCC is a lethal

  2024-12-21

  

  Renal Cell Carcinoma (RCC) is a lethal cancer with bad prognosis due to development of chemoresistance and recurrence of an aggressive tumor with increased tumor-angiogenesis and metastasis [7]. We have found Axl and Gas6 to be differentially presented in RCC subtypes, and Axl to correlate to tumor

• other name for biotin Various cardiovascular diseases show a

  2024-12-21

  

  Various cardiovascular diseases show a high occurrence of autophagosomes. Whereas basal autophagy is required for the proper functioning of cardiomyocytes [82], the deletion of Atg5 gene in myocardium shows a high risk of cardiomyopathy [83]. Hamacher et al. observed that an upregulation of Bnip3,

• br Introduction Lung cancer is the leading

  2024-12-21

  

  Introduction Lung cancer is the leading cause of cancer death worldwide and is one of the most refractory of solid tumors along with pancreatic cancer. Since 1975 there have been notable improvements in the 5-year survival rate of patients with lung cancer [1]. This improvement in survival is tho

• The canonical binding sites to which or contribute are highl

  2024-12-20

  

  The canonical 2189 mg to which α2, α3, or α5 contribute are highly similar. Therefore, differences in ligand affinity will not be large even if a ligand makes optimal use of the small differences in the pockets. As a possible alternative approach to achieve separation of compound effects, ligands w

• Activated MAP kinases transform the stimulus

  2024-12-20

  

  Activated MAP kinases transform the stimulus into the pathophysiological responses by phosphorylating downstream substrates, including transcription factors, cytoskeletal proteins involved in mRNA translation (Li et al., 2015). Among the numerous effectors that intervene in the TNF-α action is an ac

• In addition to connecting high ARG levels with

  2024-12-20

  

  In addition to connecting high ARG1 levels with DNMT3A/TET2 mutations in MDS/CMML patient biopsies, we also wanted to address the cell type demonstrating elevated ARG1. Following our mouse work, we hypothesized that overexpression of this protein would be found in myelomonocytic Calpain Inhibitor XI

• APJ receptor expression is altered in various cardiovascular

  2024-12-20

  

  APJ receptor expression is altered in various cardiovascular diseases, and both increases as well as decreases in APJ receptor expression have been reported. A decrease in mRNA and protein levels of APJ receptors was observed in patients with ischemic heart disease or idiopathic dilated cardiomyopa

• Apelin is a bioactive peptide and

  2024-12-20

  

  Apelin is a bioactive peptide and endogenous ligand for the APJ receptor (APLNR), a member of the G protein coupled receptor family that shares a similar sequence as the angiotensin type-1 receptor (AT1) [5]. Early studies demonstrated that the apelin/APLNR receptor axis plays a significant role in

• Dopaminergic neurons are vulnerable to oxidative products an

  2024-12-20

  

  Dopaminergic neurons are vulnerable to oxidative products and inflammatory responses; these processes may play important roles in the etiology of PD. Because glial cftr inhibitor are the main generators of inflammatory responses in the CNS, the possibility that PD results from glial cell dysfunctio

• Limitations of this study include the use of

  2024-12-20

  

  Limitations of this study include the use of HL-1 cardiomyocytes, which show different characteristics than primary cardiomyocytes [56]. Furthermore, sustained TAC in Ampkα1-deficient mice did not favorably influence cardiac function [33]. It must be kept in mind that global Ampkα1-deficiency may af

• The subnuclear localizations of redox regulators is

  2024-12-20

  

  The subnuclear localizations of redox regulators is also largely unknown. The potential role of thiol reductases as transcription regulators or DNA repair molecules may suggest an association to DNA. In this way, the presence of a zinc finger domain potentially involved in protein/DNA interactions o

• br G protein activation through croaker ZIP An essential cri

  2024-12-20

  

  G protein activation through croaker ZIP9 An essential criterion for designating a steroid binding protein as a membrane steroid receptor is to demonstrate that it can transduce steroid signals in order to elicit a cellular response. Treatment with 100nMT caused G protein activation in croaker ZI

• In our sequential model for tau and A deposition

  2024-12-20

  

  In our sequential model for tau and Aβ deposition, we included the tau deposition in the medial temporal inhibitor of apoptosis proteins in the absence of Aβ deposition, which is a pathological definition of primary age-related tauopathy (PART). Although the tau pathologies in PART and AD are almos

• Aerobic exercise plays an important

  2024-12-20

  

  Aerobic exercise plays an important role in the regulation of Mitochondrial DNA Isolation Kit metabolism in the skeletal muscle. It is also associated with increases in AMPK and GLUT4 levels, resulting in the improvement of the glucose uptake signaling pathway [17,18]. Recently, it has been shown t

14639 records 37/976 page Previous Next First page 上5页 3637383940 下5页 Last page