• Nonivamide (Capsaicin Analog): Unlocking TRPV1 Agonism fo...

  2025-09-26

  Explore how Nonivamide, a capsaicin analog and potent TRPV1 receptor agonist, drives advanced cancer cell growth inhibition and inflammation control through mitochondrial apoptosis pathways. This article uniquely integrates molecular mechanisms with emerging neuroimmune insights, offering a deeper perspective for researchers.

• EZ Cap Cy5 Firefly Luciferase mRNA: Next-Generation Tools...

  2025-09-25

  Explore how EZ Cap Cy5 Firefly Luciferase mRNA leverages 5-moUTP modification and Cap1 capping for advanced mRNA delivery, enhanced translation efficiency, and innate immune suppression. This comprehensive analysis provides unique insights into its mechanism and future biotechnology applications.

• EZ Cap Cy5 Firefly Luciferase mRNA: A Dual-Mode Platform ...

  2025-09-24

  Discover how EZ Cap Cy5 Firefly Luciferase mRNA (5-moUTP) enables dual-mode detection and advanced mRNA delivery, uniquely bridging fluorescent and bioluminescent readouts for translational research. Explore the mechanistic foundations, in vivo applications, and scientific insights that set this Cap1 capped, 5-moUTP modified mRNA apart.

• Advancing In Vivo mRNA Imaging: EZ Cap Cy5 Firefly Lucife...

  2025-09-23

  Explore how EZ Cap Cy5 Firefly Luciferase mRNA (5-moUTP) enables precise, dual-mode visualization and functional assays in mammalian systems. This article examines its role in suppressing innate immune activation, enhancing mRNA stability, and supporting rigorous translation efficiency assays.

• EZ Cap Cy5 Firefly Luciferase mRNA: Enhancing mRNA Delive...

  2025-09-22

  Explore the scientific foundations and unique properties of EZ Cap Cy5 Firefly Luciferase mRNA (5-moUTP), a Cap1 capped, fluorescently labeled mRNA designed for improved mammalian expression, transfection, and in vivo imaging. This article highlights the latest research and practical considerations for using 5-moUTP modified mRNA in advanced biomedical applications.

• 5-moUTP Modified EZ Cap Cy5 Firefly Luciferase mRNA: Adva...

  2025-09-19

  Explore how EZ Cap Cy5 Firefly Luciferase mRNA (5-moUTP) provides enhanced mRNA stability, reduced innate immune activation, and dual-mode detection through Cy5 fluorescence and luciferase bioluminescence for advanced mammalian expression research.

• Innovative Applications of EZ Cap Cy5 Firefly Luciferase ...

  2025-09-18

  Explore how EZ Cap Cy5 Firefly Luciferase mRNA (5-moUTP), a 5-moUTP modified, Cap1-capped, and fluorescently labeled mRNA, advances mRNA delivery, translation efficiency assays, and in vivo bioluminescence imaging for mammalian systems.

• To further clarify the vascular cell types

  2025-03-03

  

  To further clarify the vascular cell types expressing AR subtypes, double immunofluorescence staining for ARs and vascular endothelial Hydroxysafflor yellow A or vascular smooth muscles was performed. As shown in Fig. 3, Fig. 4, overlay images show the expression of all ARs subtypes that we examine

• br Methods br Results br Discussion Chronic stress renders i

  2025-03-03

  

  Methods Results Discussion Chronic stress renders individuals vulnerable to diseases, and this effect might be, at least partially, mediated by stress hormone-induced immunosuppression. Therefore, investigating the effects of catecholamines on immune ionophores is of high relevance. We hypo

• rosavin In previous research we determined that blocking

  2025-03-03

  

  In previous research, we determined that blocking mAC during heparin-induced capacitation result in sperm having a lesser oxygen consumption, suggesting that cAMP produced by this enzyme would be linked to mitochondrial activity and, therefore, with the regulation of sperm metabolism (Fernández and

• Adenosine can modulate neutrophil bactericidal functions A d

  2025-03-03

  

  Adenosine can modulate neutrophil bactericidal functions. A dual regulatory effect has been reported for adenosine on phagocytosis. Indeed, the activation of A1 receptors augments this process, while the stimulation of A2A receptors was found to reduce the phagocytic activity of neutrophils [89]. In

• In conclusion we have demonstrated that diaryl pyrazolo pyri

  2025-03-03

  

  In conclusion, we have demonstrated that ,-diaryl-1-pyrazolo[3,4-]pyrimidine-3,6-diamines represent a novel class of ACK1 inhibitors. The presence of a polar substituent at C-4 of the N-6 aryl ring was shown to be unnecessary for maintaining high levels of inhibitory activity. Furthermore, selectivi

• Benzoylmesaconitine br Difference between ACh and ER tests T

  2025-03-03

  

  Difference between ACh and ER tests There are few reports concerning the provoked spasm between ER and ACh in the same patients [51], [52], [53]. Different mediators may have the potential of different coronary responses. In our experience, spasm provoked by intracoronary injection of ER is focal

• br Conclusion There have been multiple

  2025-03-03

  

  Conclusion There have been multiple clinical trials and pre-clinical studies that have tested the utility of 5ARIs in treating prostate disease, as summarized in Fig. 1. Inhibiting androgen action through the use of finasteride and dutasteride has been established as a valuable resource for physi

• The molecular mechanisms involved in the pathogenesis

  2025-03-03

  

  The molecular mechanisms involved in the pathogenesis of cholestatic pruritus remain unknown [45], [46]. Indeed, there has been an enormous effort at understanding the etiology of PBC-related pruritus, including work at the cellular and molecular level, but such efforts have not been translated into

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